Son of Aegeon and husband of Adriana, Antipholus of Ephesus is a philandering rogue who never seems to be home, which leaves his wife wanting. A charming, sometimes-principled man of status in the city, he is addressed by the citizens as “Sir.” When mistaken for his brother, he impulsively reacts with brute force.

A stranger to the town of Ephesus, Antipholus of Syracuse is a decent and unpretentious man. He is baffled by his circumstances, as he is constantly mistaken for a charismatic man of great authority. Unmarried and affable, he instantly falls in love with Luciana while being pursued by Adriana, who believes he is her husband.

Doting servant to Antipholus of Ephesus, Dromio E. is efficient, clever and loyal. He is husband to a dominating and demanding wife, Luce, who keeps him under a watchful eye.

Goofy but likeable, Dromio is servant to Antipholus of Syracuse. Simple-minded and easily confused, he is continually baffled by his perplexing circumstances.

Dromio of Ephesus' insistent wife, Luce is strong and unafraid, keeping her husband in check while he is off serving his Antipholus. When she mistakes Dromio of S. for her Dromio, she's staggered by his sudden reticence towards her.

Antipholus of E.'s wife, Adriana is well-meaning but pompous. Trying to make the best of the stay-at-home life, she believes that, unlike other women, she knows the true meaning of love. When her husband seems more distant than usual, she resolves to win him back.

Adriana's younger sister, Luciana dreams of falling in love with a man who returns her affection. Idealistic and romantic, she falls for Antipholus S., whom she believes is her sister’s husband. Though she knows her feelings are inappropriate, she cannot deny them.

An aging father of twin sons (Antipholus of Ephesus and Antipholus of Syracuse), Aegeon travels from Syracuse to Ephesus to find his two long-lost boys. Regarded as an enemy of the state, he is immediately sentenced to execution.